regulation of transforming growth factorβ1driven lung fibrosis by galectin3
Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 08:22
... an in vitro measure of the in vivo
efficiency of TGF-β
1
activation
To examine the ability of SLE patients and control individuals
to activate TGF-β
1
, a ratio of levels of TGF-β
1
in freshly ... development of early
atherosclerosis.
Introduction
Transforming growth factor (TGF)-β
1
is the most potent natu-
rally occurring immunosuppressant [1]; it is produced by all
cells of the immune ... proliferation and the fate of cells through apoptosis.
In TGF-β
1
knockout mice [2] lack of TGF-β
1
initiates indiscrim-
inate loss of self-tolerant T cells. Consequential dysregulation
of B cell activity...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
Ngày tải lên :
07/03/2014, 01:20
... go to only one of the
two daughter cells, leaving the other relatively clear of
such signaling byproducts. A deeper understanding of
the role of microtubules in the regulation of Smad
trafficking ... localization of transforming growth factor-
beta in idiopathic pulmonary fibrosis. Am J Respir Cell
Mol Biol 5, 155–162.
153 Broekelmann TJ, Limper AH, Colby TV & McDonald
JA (1991) Transforming growth ... characterized by the
dissolution of epithelial cell–cell junctions and reorga-
nization of the actin cytoskeleton with the formation
of focal adhesions and stress fibers, acquisition of a
spindle-shaped...
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Báo cáo khoa học: Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases docx
Ngày tải lên :
23/03/2014, 07:20
... concentration of 1 mm, and this was followed by the
addition of 100 ng of each KLK. The final volume of each
mixture was 150 lL. The enzymatic activity was monitored
by the release of p-nitroaniline ... Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
2 Department of Urology, Faculty of Medicine, University of Miyazaki, ... surface of various epithelial cells and
Fig. 4. Analysis of cleavage sites of pro-HGFA by KLKs. (A) Time-dependent cleavage patterns of pro-HGFA (52 nM) were analyzed by using
three kinds of antibody...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
Ngày tải lên :
18/06/2014, 15:20
... activation of mesenchymal HSCs. This
interpretation is strengthened by the findings of a negative
correlation of serum TGF-β1 with fibrosis score, feature of
stable collagen deposition, and by a good ... biopsy-proven diagnosis.
Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin.
Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... Medical
School of Naples, Department of Biochemistry and Medical Biotechnology, Naples, Italy and
4
Federico II University Medical School of Naples,
Department of Neurosciences, Section of Clinical...
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- 0
Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
Ngày tải lên :
09/08/2014, 01:21
... Robbins
1
1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
2
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, ... clinical
applications of transforming growth factor-beta (TGF-beta).
Growth Factors 1993, 8:1-9.
3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB:
Transforming growth factor-beta in ... sequence analysis of simian transforming growth
factor-beta cDNA. DNA 1987, 6:239-244.
5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming
growth factor-beta. A family of growth regulatory peptides.
Ann...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
Ngày tải lên :
18/02/2014, 13:20
... lg of pcDL-SRa
296JNK2(VPF) or pcMKP-1 and 1.5 lg of pBabePuro by
using the Lipofectamine reagent, and the transfected cells
were selected by exposure to 2.5 mg of puromycin (Sigma)
per mL of ... Department of Genome Biology, Kinki University School of Medicine, Osaka, Japan
Epidermal growth factor receptor (EGFR), a member
of the ErbB family, is important in the regulation of
growth, differentiation ... level
of MKP-2 was not affected by AG1478 treatment,
indicating that the expression of MKP-1, but not that
of MKP-2, is controlled by signals via EGFRs.
Brondello et al. reported that activation of...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
Ngày tải lên :
15/03/2014, 11:20
... of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA
Keywords
mTOR; rapamycin; TSC1; TSC2; wortmannin
Correspondence
K. A. Esser, Department of Physiology,
College of ... influences mTOR signaling by
regulation of the protein complex of tuberous sclerosis
complex (TSC)1 ⁄ TSC2 [9–12]. The TSC1 ⁄ TSC2 pro-
tein complex is a heterodimer composed of the TSC1
and TSC2 ... it is clear that growth factor-
induced activation of Akt blocks TSC1 ⁄ TSC2 inhibi-
tion of mTOR signaling [9–11], the molecular mecha-
nism by which Akt inhibits the function of
TSC1 ⁄ TSC2 protein...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
Ngày tải lên :
22/03/2014, 21:21
... anti-inflammatory
cytokine transforming growth factor-b1 (TGF-b1) of
the proinflammatory cytokine TNF-a via the induction
of FXR1 is the focus of this article.
TGF-b1, a member of the large transforming growth
factor-b ... expression of several other proinflammatory
proteins was also affected by FXR1 deficiency, but the
cytokines involved in the induction of FXR1 remain un-
characterized. The regulation by the anti-inflammatory
cytokine ... also dem-
onstrate that this process is regulated by TGF-b1.
Induction of FXR1 expression by TGF-b1 leads to
post-transcriptional downregulation of TNF-a
protein
Many RNA-binding proteins, such...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
Ngày tải lên :
31/03/2014, 23:20
... its down -regulation by
TGF-b
1
.
DISCUSSION
The inhibition by TGF-b
1
of SeP expression is to date the
only known regulation of this protein by a factor other than
the availability of selenium. ... Cell-specific regulation of human arylhydrocarbon
receptor expression by transforming growth factor-b
1
. Mol.
Pharmacol. 59, 716 724.
22. Do
ă
hr, O. & Abel, J. (1997) Transforming growth factor-beta ... point-mutation of
putative SBEs led to a loss of promoter sensitivity towards
TGF-b
1
treatment. Hence, we demonstrated an involvement
of Smad 3 and 4 in transcriptional regulation of SeP by
TGF-b
1
and...
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- 1
Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
Ngày tải lên :
18/06/2014, 16:20
... key role in the growth and development of nor-
mal tissue. However, aberrations of this molecular path-
way such as overexpression of IGF1R, elevated plasma
levels of IGF1, loss of IGF2 imprinting, ... such
as receptor upregulation or overexpression of l igands
driven by multiple mechanisms like fusion genes
(PAX3-FKHR; EWS-WT1; EWS-FLI1), loss of imprint-
ing (LOI) of IGF2, or loss of tumor suppressor ... al. Journal of Translational Medicine 2010, 8:117
http://www.translational-medicine.com/content/8/1/117
Page 2 of 6
COMM E N T ARY Open Access
The emerging role of insulin-like growth factor
1...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
Ngày tải lên :
19/06/2014, 22:20
... obstruction of CSF clearance by
meningeal fibrosis [34,35]. Other examples exist of
hydrocephalus caused by growth factor-induced fibrosis
[36]. The site and mechanism of action of pioglitazone ... degradation of Aβ42. Also
ibuprofen has been shown to reduce plaque-associated
and soluble Aβ42 in mice over-expressing the Swedish
mutation of human APP [15,16]. The lack of effect of ibu-
profen in ... resolution of injuries by inhib-
iting local inflammation, and by stimulating the synthesis
and deposition of matrix components leading to the
reconstitution of the basal membrane in the final stages of
angiogenesis....
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc
Ngày tải lên :
09/08/2014, 01:21
... increase of IGF-1 in this trial is
caused by estrogen-mediated reduction of the IL-6/sIL-6R
pathway or by effects on the GH/IGF-1 axis or by a combi-
nation of these mechanisms.
Administration of IL-1Ra ... to these direct effects on bone cells,
the major action of estrogens in vivo is believed to be
mostly by indirect actions, regulation of growth factors and
cytokines in osteoblasts, which in turn ... one of the key mediators of increased bone loss in
postmenopausal women. Production of this cytokine by
mononuclear blood cells increases with age and
menopause [21] and is inhibited in vitro by...
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- 0
Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
Ngày tải lên :
09/08/2014, 01:23
... act independently of the
inhibition of IGF-1-binding to IGFBPs. However, an
Figure 5
Comparative activity of NBI-31772, a small-molecule inhibitor of the binding of insulin-like growth factor (IGF)-1 ... mutant of IGF-1 with strongly decreased affin-
ity for IGFBPs was able to stimulate the synthesis of
Figure 4
Effect of NBI-31772, a small-molecule inhibitor of the binding of insulin-like growth ... severity of the disease [26]. The molar
concentration of IGFBP-3 in the synovial fluid of OA
patients was higher than that of IGF-1, leading to a molar
ratio of free to bound IGF-1 of less than...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
Ngày tải lên :
09/08/2014, 07:20
... RT, Heydemann A, Izumi T, Reddi AH: Regulation of the
expression of the type-II collagen gene in periosteum-derived
cells by three members of the transforming growth factor-beta
superfamily. J ... tibia.
Figure 3
Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta
in ... postulate that the lack of responsiveness to TGF-beta
counteraction of IL-1 in old mice is due to an overall lack of
responsiveness to TGF-beta caused by a down regulation of
receptors and/or Smad...
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- 0
Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
Ngày tải lên :
09/08/2014, 10:20
... levels of active
TGF-β1 have recently been reported in RA synovial fluid in
Figure 2
mRNA-expression of the transforming growth factor (TGF)-β related genesmRNA-expression of the transforming growth ... downregulated.
Upregulation of TGF-β1 and THBS1 mRNA (both positively
correlated with clinical markers of disease activity/severity) and
downregulation of TGF-β2 mRNA in RA SFBs were confirmed
by qPCR. ... Analy-sis of the oligonucleotide microarray dataCentral components of the transforming growth factor (TGF)-β pathway are shown with their scores, as determined by Gene Set Enrichment Analy-
sis of the...
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